Murine breast cancer feed arteries are thin-walled with reduced α1A-adrenoceptor expression and attenuated sympathetic vasocontraction

Murine breast cancer feed arteries are thin-walled with reduced α1A-adrenoceptor expression and attenuated sympathetic vasocontraction

Abstract Background Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possible therapeutic targets in mature cancer arteries, we here characterize t...

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Bibliographic Details
Main Authors: Anne Sofie Froelunde, Marit Ohlenbusch, Kristoffer B. Hansen, Nicolai Jessen, Sukhan Kim, Ebbe Boedtkjer
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Breast Cancer Research
Subjects:
Adrenergic receptors
Arterial structure
Breast cancer
Sympathetic nerve activity
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13058-018-0952-8

Internet

http://link.springer.com/article/10.1186/s13058-018-0952-8

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