Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The struct...

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Bibliographic Details
Main Authors: Ali Fattahi, Mansoureh Ghiasi, Pardis Mohammadi, Leila Hosseinzadeh, Khosro Adibkia, Ghobad Mohammadi
Format: Article
Language:English
Published: Universidade de São Paulo 2019-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Nanoparticle
PLGA
Flutamide
Prazosin
Prostate cancer
Drug delivery
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400609&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400609&lng=en&tlng=en

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