Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.

Bibliographic Details
Main Authors: Pingsu Mao, Jingfan Liu, Zepeng Zhang, Hong Zhang, Haiying Liu, Song Gao, Yikang S. Rong, Yong Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12154

Internet

https://doi.org/10.1038/ncomms12154

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