Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Emerging evidence points to reactive glia as a pivotal factor in Parkinson's disease (PD) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of basal ganglia injury, but whether astrocytes and microglia activation may exacerbate dopaminergic (DAergic) neuron demise and...

Full description

Bibliographic Details
Main Authors: F. L'Episcopo, C. Tirolo, N. Testa, S. Caniglia, M.C. Morale, C. Cossetti, P. D'Adamo, E. Zardini, L. Andreoni, A.E.C. Ihekwaba, P.A. Serra, D. Franciotta, G. Martino, S. Pluchino, B. Marchetti
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Astroglia
Neurodegeneration
Neuroinflammation
Neuroprotection
Parkinson disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003669

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110003669

Similar Items