High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing

High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing

Staphylococcus aureus is one of the first and most prevalent pathogens cultured from the airways of cystic fibrosis (CF) patients, which can persist there for extended periods. Airway infections in CF patients are characterized by a strong inflammatory response of highly recruited neutrophils. One k...

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Bibliographic Details
Main Authors: Susann Herzog, Felix Dach, Nicole de Buhr, Silke Niemann, Jannik Schlagowski, Diego Chaves-Moreno, Claudia Neumann, Jonas Goretzko, Vera Schwierzeck, Alexander Mellmann, Angelika Dübbers, Peter Küster, Holger Schültingkemper, Ursula Rescher, Dietmar H. Pieper, Maren von Köckritz-Blickwede, Barbara C. Kahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
Cystic fibrosis
Staphylococcus aureus
neutrophil extracellular traps
nuclease
adaptation
NET-mediated killing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02552/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02552/full

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