Protamine Characterization by Top-Down Proteomics: Boosting Proteoform Identification with DBSCAN

Protamine Characterization by Top-Down Proteomics: Boosting Proteoform Identification with DBSCAN

Protamines replace histones as the main nuclear protein in the sperm cells of many species and play a crucial role in compacting the paternal genome. Human spermatozoa contain protamine 1 (P1) and the family of protamine 2 (P2) proteins. Alterations in protamine PTMs or the P1/P2 ratio may be associ...

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Bibliographic Details
Main Authors: Gianluca Arauz-Garofalo, Meritxell Jodar, Mar Vilanova, Alberto de la Iglesia Rodriguez, Judit Castillo, Ada Soler-Ventura, Rafael Oliva, Marta Vilaseca, Marina Gay
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Proteomes
Subjects:
male infertility
sperm
protamine
LC-MS/MS
top-down proteomics
proteoform
Online Access:https://www.mdpi.com/2227-7382/9/2/21

Internet

https://www.mdpi.com/2227-7382/9/2/21

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