Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study

Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study

In endothelial cells, erythropoietin receptors (EPORs) mediate the protective, proliferative and angiogenic effects of EPO and its analogues, which act as EPOR agonists. Because hormonal receptors undergo functional changes upon chronic exposure to agonists and because erythropoiesis-stimulating age...

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Bibliographic Details
Main Authors: Maria Pia Abbracchio, Simona Daniele, Serena Cuboni, Osele Ciampi, Eleonora Da Pozzo, Maria Letizia Trincavelli, Claudia Martini
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial cells
erythropoietin receptor
erythropoiesis-stimulating agents
STAT-5 pathway
receptor desensitization
signal resensitization
cell proliferation
angiogenesis
Online Access:http://www.mdpi.com/1422-0067/14/2/2258

Internet

http://www.mdpi.com/1422-0067/14/2/2258

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