Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction

Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction

The apelin and Elabela proteins constitute a spatiotemporal double-ligand system that controls apelin receptor (APJ) signal transduction. Phosphorylation of multiple sites within the C-terminus of APJ is essential for the recruitment of β-arrestins. We sought to determine the precise mechanisms by w...

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Bibliographic Details
Main Authors: Jing Chen, Xiaoyu Chen, Sheng Li, Yunlu Jiang, Huiling Mao, Rumin Zhang, Bingyuan Ji, Maocai Yan, Xin Cai, Chunmei Wang
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Apelin receptor (APJ)
Phosphorylation
Mass spectrometry
Signal transduction
Bioluminescence resonance energy transfer (BRET)
Internalization
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172030834X

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http://www.sciencedirect.com/science/article/pii/S221323172030834X

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