Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

Accumulation of mutant Huntingtin (Htt), especially the N-terminal-cleaved Htt, participates in the pathophysiology of Huntington's disease (HD). It is difficult to elucidate temporal properties of the translocation of “endogenous” Htt using autopsy HD patient brains. Thus, we examined the cell...

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Bibliographic Details
Main Authors: Akira Sawa, Eiichiro Nagata, Siobhan Sutcliffe, Pratima Dulloor, Matthew B. Cascio, Yuji Ozeki, Sophie Roy, Christopher A. Ross, Solomon H. Snyder
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Perinuclear site
Htt
Cleavage
Caspase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000732

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http://www.sciencedirect.com/science/article/pii/S0969996105000732

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