Detecting Gene-Environment Interaction for Maternal Exposures Using Case-Parent Trios Ascertained Through a Case With Non-Syndromic Orofacial Cleft

Detecting Gene-Environment Interaction for Maternal Exposures Using Case-Parent Trios Ascertained Through a Case With Non-Syndromic Orofacial Cleft

Two large studies of case–parent trios ascertained through a proband with a non-syndromic orofacial cleft (OFC, which includes cleft lip and palate, cleft lip alone, or cleft palate alone) were used to test for possible gene–environment (G × E) interaction between genome-wide markers (both observed...

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Bibliographic Details
Main Authors: Wanying Zhang, Sowmya Venkataraghavan, Jacqueline B. Hetmanski, Elizabeth J. Leslie, Mary L. Marazita, Eleanor Feingold, Seth M. Weinberg, Ingo Ruczinski, Margaret A. Taub, Alan F. Scott, Debashree Ray, Terri H. Beaty
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
orofacial clefts
oral clefts
gene-environment interaction
case-parent trio design
genome-wide association study
maternal smoking
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.621018/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.621018/full

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