Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain

Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain

Abstract Background Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play a key role in orchestrating this detrimental triad. ALIAmides down-modulate mast cells and more generally h...

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Bibliographic Details
Main Authors: Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Ramona D’ Amico, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Roberta Fusco, Rosanna Di Paola, Carlo Schievano, Salvatore Cuzzocrea
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Pain
Mast cells
ALIAmides
N-palmitoyl-D-glucosamine
Palmitoylethanolamide
Online Access:https://doi.org/10.1186/s13075-019-2048-y

Internet

https://doi.org/10.1186/s13075-019-2048-y

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