TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.

TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.

Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially regulates mTOR complex 1 (mTORC1) and mTORC2/Akt signaling in B cells. TSC1 d...

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Bibliographic Details
Main Authors: Xinxin Ci, Masayuki Kuraoka, Hongxia Wang, Zachary Carico, Kristen Hopper, Jinwook Shin, Xuming Deng, Yirong Qiu, Shyam Unniraman, Garnett Kelsoe, Xiao-Ping Zhong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4441391?pdf=render

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http://europepmc.org/articles/PMC4441391?pdf=render

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