Recessive Cancer Genes Engage in Negative Genetic Interactions with Their Functional Paralogs

Recessive Cancer Genes Engage in Negative Genetic Interactions with Their Functional Paralogs

Cancer genetic heterogeneity offers a wide repertoire of molecular determinants to be screened as therapeutic targets. Here, we identify potential anticancer targets by exploiting negative genetic interactions between genes with driver loss-of-function mutations (recessive cancer genes) and their f...

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Bibliographic Details
Main Authors: Matteo D’Antonio, Rosalinda F. Guerra, Matteo Cereda, Stefano Marchesi, Francesca Montani, Francesco Nicassio, Pier Paolo Di Fiore, Francesca D. Ciccarelli
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713007006

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http://www.sciencedirect.com/science/article/pii/S2211124713007006

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