Bioenergetic consequences of PINK1 mutations in Parkinson disease.

Bioenergetic consequences of PINK1 mutations in Parkinson disease.

BACKGROUND:Mutations of the gene for PTEN-induced kinase 1 (PINK1) are a cause of familial Parkinson's disease (PD). PINK1 protein has been localised to mitochondria and PINK1 gene knockout models exhibit abnormal mitochondrial function. The purpose of this study was to determine whether cells...

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Bibliographic Details
Main Authors: Andrey Yurevich Abramov, Matthew Gegg, Anne Grunewald, Nicholas William Wood, Christine Klein, Anthony Henry Vernon Schapira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3197155?pdf=render

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http://europepmc.org/articles/PMC3197155?pdf=render

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