Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model

Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model

Compared to two-dimensional (2D) cell culture, cellular aggregates or spheroids (3D) offer a more appropriate alternative in vitro system where individual cell-cell communication and micro-environment more closely represent the in vivo organ; yet we understand little of the physiological conditions...

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Bibliographic Details
Main Authors: Laura M. Langan, Stewart F. Owen, Maciej Trznadel, Nicholas J. F. Dodd, Simon K. Jackson, Wendy M. Purcell, Awadhesh N. Jha
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
spheroids
EPR-oximetry
micro-environment
metabolism
intestine
β-blocker
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00947/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00947/full

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