Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging
Abstract Background In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2018-02-01
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Series: | EJNMMI Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13550-018-0372-x |