ATP activates bestrophin ion channels through direct interaction

ATP activates bestrophin ion channels through direct interaction

Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

Bibliographic Details
Main Authors: Yu Zhang, Alec Kittredge, Nancy Ward, Changyi Ji, Shoudeng Chen, Tingting Yang
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05616-4

Internet

https://doi.org/10.1038/s41467-018-05616-4

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