Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach

Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach

The chemical synthesis of modified oligoribonucleotides represents a powerful approach to study the structure, stability, and biological activity of RNAs. Selected RNA modifications have been proven to enhance the drug-like properties of RNA oligomers providing the oligonucleotide-based therapeutic...

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Bibliographic Details
Main Authors: Karolina Bartosik, Katarzyna Debiec, Anna Czarnecka, Elzbieta Sochacka, Grazyna Leszczynska
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
phosphoramidite chemistry
RNA solid-phase synthesis
post-synthetic RNA modification
convertible nucleoside
Online Access:https://www.mdpi.com/1420-3049/25/15/3344

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https://www.mdpi.com/1420-3049/25/15/3344

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