PRDM14 controls X-chromosomal and global epigenetic reprogramming of H3K27me3 in migrating mouse primordial germ cells

PRDM14 controls X-chromosomal and global epigenetic reprogramming of H3K27me3 in migrating mouse primordial germ cells

Abstract Background In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a genome-wide scale and additionally in females the remodeling of the inacti...

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Bibliographic Details
Main Authors: Anna Mallol, Maria Guirola, Bernhard Payer
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Epigenetics & Chromatin
Subjects:
PRDM14
X-chromosome reactivation
PGCs
Epigenetic reprogramming
H3K27me3
Mouse
Online Access:http://link.springer.com/article/10.1186/s13072-019-0284-7

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http://link.springer.com/article/10.1186/s13072-019-0284-7

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