Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose

Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose

Type 2 diabetes (T2D) is a major risk factor for heart failure. Diabetic cardiomyopathy (DC) is characterized by diastolic dysfunction and left ventricular hypertrophy. Epidemiological data suggest that hyperglycaemia contributes to the development of DC. Several cellular pathways have been implicat...

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Bibliographic Details
Main Authors: Simon Ducheix, Jocelyne Magré, Bertrand Cariou, Xavier Prieur
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
glucotoxicity
diabetes
metabolism
cardiomyopathy
O-GlcNAcylation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00642/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00642/full

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