Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss.

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss.

Our preliminary findings have lead us to propose bone marrow adipocyte secretions as new contributors to bone loss. Indeed, using a coculture model based on human bone marrow stromal cells, we previously showed that soluble factors secreted by adipocytes induced the conversion of osteoblasts towards...

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Bibliographic Details
Main Authors: Aline Clabaut, Céline Grare, Gaëlle Rolland-Valognes, Jean-Guillaume Letarouilly, Chantal Bourrier, Thomas L Andersen, Tanja Sikjær, Lars Rejnmark, Charlotte Ejersted, Philippe Pastoureau, Pierre Hardouin, Massimo Sabatini, Odile Broux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0245014

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https://doi.org/10.1371/journal.pone.0245014

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