CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas

CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas

Cyclin-Dependent Kinases (CDKs) are well-known reliable targets for cancer treatment being often deregulated. Among them, since the transcription-associated CDK9 represents the sentry of cell transcriptional homeostasis, it can be a valuable target for managing cancers in which the transcriptional m...

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Bibliographic Details
Main Authors: Matteo Cassandri, Rossella Fioravanti, Silvia Pomella, Sergio Valente, Dante Rotili, Giada Del Baldo, Biagio De Angelis, Rossella Rota, Antonello Mai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
natural inhibitors
CDK9
pediatric sarcoma
gene transcription
chromosomal translocation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01230/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01230/full

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