Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF.

Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF.

ABSTRACTBackgroundAmyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a dru...

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Bibliographic Details
Main Authors: Alexandre eHenriques, Stefan eKastner, Eva eChatzikonstantinou, Claudie ePitzer, Christian ePlaas, Friederike eKirsch, Oliver eWafzig, Krüger eCarola, Robert eSpoelgen, Jose-Luis eGonzalez De Aguilar, Norbert eGretz, Armin eSchneider
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Gene Expression
motoneuron
neurodegeneration
ALS
laser microdissection
G-CSF
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00464/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00464/full

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