Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus, functional β-cell replacement from renewable sources is the focus of intensive worldwide effort. However, in vitro production of progeny that secrete insulin in response to physiological cues from primary human...

Full description

Bibliographic Details
Main Authors: Jonghyeob Lee, Takuya Sugiyama, Yinghua Liu, Jing Wang, Xueying Gu, Ji Lei, James F Markmann, Satsuki Miyazaki, Jun-ichi Miyazaki, Gregory L Szot, Rita Bottino, Seung K Kim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-11-01
Series:eLife
Subjects:
diabetes
islet
pancreas
beta-cell
insulin
conversion
Online Access:https://elifesciences.org/articles/00940

Internet

https://elifesciences.org/articles/00940

Similar Items