Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells
Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus, functional β-cell replacement from renewable sources is the focus of intensive worldwide effort. However, in vitro production of progeny that secrete insulin in response to physiological cues from primary human...
Main Authors: | Jonghyeob Lee, Takuya Sugiyama, Yinghua Liu, Jing Wang, Xueying Gu, Ji Lei, James F Markmann, Satsuki Miyazaki, Jun-ichi Miyazaki, Gregory L Szot, Rita Bottino, Seung K Kim |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/00940 |
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