Overexpression of the Small RNA PA0805.1 in Pseudomonas aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance

Overexpression of the Small RNA PA0805.1 in Pseudomonas aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance

P. aeruginosa is an opportunistic pathogen of humans. With roughly 10% of its genes encoding transcriptional regulators, and hundreds of small noncoding RNAs (sRNAs) interspersed throughout the genome, P. aeruginosa is able to fine-tune its response to adapt and survive in the host and resist antimi...

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Bibliographic Details
Main Authors: Shannon R. Coleman, Maren L. Smith, Victor Spicer, Ying Lao, Neeloffer Mookherjee, Robert E. W. Hancock
Format: Article
Language:English
Published: American Society for Microbiology 2020-05-01
Series:mSystems
Subjects:
pseudomonas aeruginosa
antibiotic resistance
genomics
molecular genetics
motility
proteomics
swarming
virulence
Online Access:https://doi.org/10.1128/mSystems.00204-20

Internet

https://doi.org/10.1128/mSystems.00204-20

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