Inflammation Determines the Capacity of Allogenic Endothelial Cells to Regulate Human Treg Expansion

Inflammation Determines the Capacity of Allogenic Endothelial Cells to Regulate Human Treg Expansion

During allotransplantation, the endothelium acts as semi-professional antigen-presenting cells with the ability to activate proliferation and to promote differentiation of CD4+-T subsets. These abilities are dependent on the luminal expression of HLA class II antigens by microvascular endothelial ce...

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Bibliographic Details
Main Authors: Amy Rachael Cross, Julien Lion, Karine Poussin, Denis Glotz, Nuala Mooney
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
organ transplantation
endothelial cell
Treg
HLA class II
allogenicity
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.666531/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.666531/full

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