Optimized Threshold Inference for Partitioning of Clones From High-Throughput B Cell Repertoire Sequencing Data

Optimized Threshold Inference for Partitioning of Clones From High-Throughput B Cell Repertoire Sequencing Data

During adaptive immune responses, activated B cells expand and undergo somatic hypermutation of their B cell receptor (BCR), forming a clone of diversified cells that can be related back to a common ancestor. Identification of B cell clones from high-throughput Adaptive Immune Receptor Repertoire se...

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Bibliographic Details
Main Authors: Nima Nouri, Steven H. Kleinstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
AIRR-seq data
B-cell clonal partitioning
hierarchical clustering
optimized distance threshold
immcantation portal
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01687/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01687/full

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