Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms. This was consequence of a pH-switchable threading inter...

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Bibliographic Details
Main Authors: Poulami Jana, Filip Šupljika, Carsten Schmuck, Ivo Piantanida
Format: Article
Language:English
Published: Beilstein-Institut 2020-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
afm
circular dichroism
dna/rna recognition
fluorescence
guanidinio-carbonyl-pyrrole
naphthalene diimide
Online Access:https://doi.org/10.3762/bjoc.16.185

Internet

https://doi.org/10.3762/bjoc.16.185

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