BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives oste...

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Bibliographic Details
Main Authors: Yingnan Geng, Huichuan Duan, Liang Xu, Nevin Witman, Bingqian Yan, Zheyuan Yu, Huijing Wang, Yao Tan, Liqin Lin, Dong Li, Shanshan Bai, Regina Fritsche-Danielson, Jie Yuan, Kenneth Chien, Min Wei, Wei Fu
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01606-9

Internet

https://doi.org/10.1038/s42003-020-01606-9

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