An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7.

Group A streptococcus (GAS; Streptococcus pyogenes) is a common pathogen that invades non-phagocytic human cells via endocytosis. Once taken up by cells, it escapes from the endocytic pathway to the cytoplasm, but here it is contained within a membrane-bound structure termed GAS-containing autophago...

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Bibliographic Details
Main Authors: Hitomi Yamaguchi, Ichiro Nakagawa, Akitsugu Yamamoto, Atsuo Amano, Takeshi Noda, Tamotsu Yoshimori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2777386?pdf=render