IL-15 promotes human myogenesis and mitigates the detrimental effects of TNFα on myotube development

Abstract Studies in murine cell lines and in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-mediated skeletal muscle atrophy which occurs in sarcopenia and cachexia. The effects of IL-15 on human skeletal muscle growth and development remain largely unch...

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Bibliographic Details
Main Authors: Mary F. O’Leary, Graham R. Wallace, Andrew J. Bennett, Kostas Tsintzas, Simon W. Jones
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-13479-w