Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature
Double-hit lymphoma (DHL) is a rare aggressive B-cell lymphoma with concomitant c-MYC, BCL2 or BCL6 gene rearrangements, which is characterized by the high frequency of extranodal lesions and by resistance to chemotherapy. The median survival does not exceed 18 months in patients with this disease....
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"Consilium Medicum" Publishing house
2017-07-01
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Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32297/pdf |
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doaj-d33e3331a63647a29d4d8b743e50bdcf2020-11-25T03:32:38Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422017-07-01897859210.17116/terarkh201789785-9229297Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literatureN G GabeevaD A KorolevaA V BelyaevaN G ChernovaL A KuzminaA B SudarikovT N ObukhovaA M KovriginaE E ZvonkovV G SavchenkoDouble-hit lymphoma (DHL) is a rare aggressive B-cell lymphoma with concomitant c-MYC, BCL2 or BCL6 gene rearrangements, which is characterized by the high frequency of extranodal lesions and by resistance to chemotherapy. The median survival does not exceed 18 months in patients with this disease. The majority of DHL is represented by с-MYC/BCL2 cases. The combination of c-MYC/BCL6 occurs rarely (5—8%). The paper describes a case of DHL with concomitant c-MYC and BCL6 gene rearrangements, which mimics diffuse large B-cell lymphoma, leg-type.https://ter-arkhiv.ru/0040-3660/article/viewFile/32297/pdfdouble-hit lymphoma (dhl)bcl2bcl6dlbcl leg-typedhlbcl2bcl6 |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
N G Gabeeva D A Koroleva A V Belyaeva N G Chernova L A Kuzmina A B Sudarikov T N Obukhova A M Kovrigina E E Zvonkov V G Savchenko |
spellingShingle |
N G Gabeeva D A Koroleva A V Belyaeva N G Chernova L A Kuzmina A B Sudarikov T N Obukhova A M Kovrigina E E Zvonkov V G Savchenko Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature Терапевтический архив double-hit lymphoma (dhl) bcl2 bcl6 dlbcl leg-type dhl bcl2 bcl6 |
author_facet |
N G Gabeeva D A Koroleva A V Belyaeva N G Chernova L A Kuzmina A B Sudarikov T N Obukhova A M Kovrigina E E Zvonkov V G Savchenko |
author_sort |
N G Gabeeva |
title |
Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature |
title_short |
Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature |
title_full |
Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature |
title_fullStr |
Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature |
title_full_unstemmed |
Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature |
title_sort |
diffuse large b-cell lymphoma with concomitant c-myc and bcl6 gene rearrangements with primary skin involvement: a case report and a review of literature |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2017-07-01 |
description |
Double-hit lymphoma (DHL) is a rare aggressive B-cell lymphoma with concomitant c-MYC, BCL2 or BCL6 gene rearrangements, which is characterized by the high frequency of extranodal lesions and by resistance to chemotherapy. The median survival does not exceed 18 months in patients with this disease. The majority of DHL is represented by с-MYC/BCL2 cases. The combination of c-MYC/BCL6 occurs rarely (5—8%). The paper describes a case of DHL with concomitant c-MYC and BCL6 gene rearrangements, which mimics diffuse large B-cell lymphoma, leg-type. |
topic |
double-hit lymphoma (dhl) bcl2 bcl6 dlbcl leg-type dhl bcl2 bcl6 |
url |
https://ter-arkhiv.ru/0040-3660/article/viewFile/32297/pdf |
work_keys_str_mv |
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