Low Temperature Dynamic Chromatography for the Separation of the Interconverting Conformational Enantiomers of the Benzodiazepines Clonazolam, Flubromazolam, Diclazepam and Flurazepam

Low Temperature Dynamic Chromatography for the Separation of the Interconverting Conformational Enantiomers of the Benzodiazepines Clonazolam, Flubromazolam, Diclazepam and Flurazepam

Benzodiazepines (BZDs) are an important class of psychoactive drugs with hypnotic-sedative, myorelaxant, anxiolytic and anticonvulsant properties due to interaction with the GABAa receptor in the central nervous system of mammals. BZDs are interesting both in clinical and forensic toxicology for the...

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Bibliographic Details
Main Authors: Roberta Franzini, Alessia Rosetti, Claudio Villani
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Symmetry
Subjects:
conformational enantiomers
chirality
chiral stationary phases
benzodiazepines
low temperature dynamic chromatography
enantiomerization
Online Access:https://www.mdpi.com/2073-8994/13/6/1012

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https://www.mdpi.com/2073-8994/13/6/1012

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