Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo

Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo

Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease, cleaving IGF inhibitors, i.e., IGF binding proteins (IGFBPs), thereby setting free IGFs. The insulin/IGF-axis is involved in cancer in genera...

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Bibliographic Details
Main Authors: Andreas Kirschner, Melanie Thiede, Thomas G. P. Grünewald, Rebeca Alba Rubio, Günther H. S. Richter, Thomas Kirchner, Dirk H. Busch, Stefan Burdach, Uwe Thiel
Format: Article
Language:English
Published: Taylor & Francis Group 2017-02-01
Series:OncoImmunology
Subjects:
allogeneic
ewing sarcoma
pappa
pappalysin
t cell therapy
transgenic tcr
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1273301

Internet

http://dx.doi.org/10.1080/2162402X.2016.1273301

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