Intensive Distribution of G<sub>2</sub>-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands

Intensive Distribution of G<sub>2</sub>-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands

Guanine-rich sequences in the genomes of herpesviruses can fold into G-quadruplexes. Compared with the widely-studied G<sub>3</sub>-quadruplexes, the dynamic G<sub>2</sub>-quadruplexes are more sensitive to the cell microenvironment, but they attract less attention. Pseudorab...

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Bibliographic Details
Main Authors: Hui Deng, Bowen Gong, Zhiquan Yang, Zhen Li, Huan Zhou, Yashu Zhang, Xiaohui Niu, Sisi Liu, Dengguo Wei
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
alphaherpesviruses
pseudorabies virus
genome
G-quadruplex
G-quadruplex ligand
nucleic acids conformation
regulatory element
Online Access:https://www.mdpi.com/1420-3049/24/4/774

Internet

https://www.mdpi.com/1420-3049/24/4/774

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