CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis

CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis

Age-related macular degeneration is characterized by the formation of drusen containing amyloid-β (Aβ) and the degeneration of photoreceptors. To explore the largely unknown role of Aβ in the retina, we investigated the effects on photoreceptors of the oligomeric form of Aβ(1–42). Subretinal injecti...

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Bibliographic Details
Main Authors: Julien Bruban, Agathe Maoui, Naïma Chalour, Na An, Laurent Jonet, Charles Feumi, Jacques Tréton, Florian Sennlaub, Francine Behar-Cohen, Frédéric Mascarelli, Virginie Dinet
Format: Article
Language:English
Published: Elsevier 2011-04-01
Series:Neurobiology of Disease
Subjects:
Retina
Microglial cells
Inflammation
Oxidative stress
Age-related macular degeneration
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000052

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http://www.sciencedirect.com/science/article/pii/S0969996111000052

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