The Assembly Switch Mechanism of FtsZ Filament Revealed by All-Atom Molecular Dynamics Simulations and Coarse-Grained Models

The Assembly Switch Mechanism of FtsZ Filament Revealed by All-Atom Molecular Dynamics Simulations and Coarse-Grained Models

Bacterial cytoskeletal protein FtsZ binds and hydrolyzes GTP, and assembles into dynamic filaments that are essential for cell division. Here, we used a multi-scale computational strategy that combined all-atom molecular dynamics (MD) simulations and coarse-grained models to reveal the conformationa...

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Bibliographic Details
Main Authors: Dashuai Lv, Jingyuan Li, Sheng Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Microbiology
Subjects:
FtsZ
molecular dynamics simulation
assembly
cooperative
conformational transition
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.639883/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.639883/full

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