Ultra-bright Raman dots for multiplexed optical imaging

Raman-based imaging of biomarkers is often challenging due to low sensitivity. Here, the authors use a swelling-diffusion approach to develop a series of Raman probes that are both ultra-bright and compact in size, and demonstrate multiplexed imaging of specific protein targets in cells and tissue s...

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Bibliographic Details
Main Authors: Zhilun Zhao, Chen Chen, Shixuan Wei, Hanqing Xiong, Fanghao Hu, Yupeng Miao, Tianwei Jin, Wei Min
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21570-0