Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

Abstract Background Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that...

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Bibliographic Details
Main Authors: Jan Budczies, Carsten Denkert, Balázs Győrffy, Peter Schirmacher, Albrecht Stenzinger
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Medical Genomics
Subjects:
Cancer
Immunotherapy
PD-L1
DNA copy number alterations
Chromosome 9p gain
Online Access:http://link.springer.com/article/10.1186/s12920-017-0308-8

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http://link.springer.com/article/10.1186/s12920-017-0308-8

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