Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy

Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy

Abnormal activation of the insulin-like growth factor-I receptor (IGF-IR) occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis. IGF-IR overexpression has been proposed as a diagnostic biomarker for early-stage hepatocellular carcinoma (HCC) as well as a novel target...

Full description

Bibliographic Details
Main Author: YAN Xiaodi
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2013-06-01
Series:Linchuang Gandanbing Zazhi
Subjects:
liver neoplasms; receptor
IGF type I; antibodies
monoclonal; microRNAs，
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=5384&ClassID=5693339
id doaj-d34e6d1ed96d43fb94e2d7f24d2cb41c
record_format Article
spelling doaj-d34e6d1ed96d43fb94e2d7f24d2cb41c2020-11-24T23:34:10ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562013-06-01296473476Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy YAN Xiaodi0Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, ChinaAbnormal activation of the insulin-like growth factor-I receptor (IGF-IR) occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis. IGF-IR overexpression has been proposed as a diagnostic biomarker for early-stage hepatocellular carcinoma (HCC) as well as a novel target for HCC therapy. This review summarizes the recent research of the IGF-IR signaling pathway's abnormal activation in HCC and the results of molecular targeting studies.http://www.lcgdbzz.org/qk_content.asp?id=5384&ClassID=5693339liver neoplasms; receptorIGF type I; antibodiesmonoclonal; microRNAs，
collection DOAJ
language zho
format Article
sources DOAJ
author YAN Xiaodi
spellingShingle YAN Xiaodi
Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy
Linchuang Gandanbing Zazhi
liver neoplasms; receptor
IGF type I; antibodies
monoclonal; microRNAs，
author_facet YAN Xiaodi
author_sort YAN Xiaodi
title Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy
title_short Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy
title_full Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy
title_fullStr Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy
title_full_unstemmed Abnormal activation of insulin-like growth factor-I receptor in hepatocellular carcinoma and potential of IGF-IR targeted therapy
title_sort abnormal activation of insulin-like growth factor-i receptor in hepatocellular carcinoma and potential of igf-ir targeted therapy
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2013-06-01
description Abnormal activation of the insulin-like growth factor-I receptor (IGF-IR) occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis. IGF-IR overexpression has been proposed as a diagnostic biomarker for early-stage hepatocellular carcinoma (HCC) as well as a novel target for HCC therapy. This review summarizes the recent research of the IGF-IR signaling pathway's abnormal activation in HCC and the results of molecular targeting studies.
topic liver neoplasms; receptor
IGF type I; antibodies
monoclonal; microRNAs，
url http://www.lcgdbzz.org/qk_content.asp?id=5384&ClassID=5693339
work_keys_str_mv AT yanxiaodi abnormalactivationofinsulinlikegrowthfactorireceptorinhepatocellularcarcinomaandpotentialofigfirtargetedtherapy
_version_ 1725529451801870336

Similar Items