K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model

K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model

Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat. During inflammation, TRPV1 is reported to be sensitized by protein kinase C (PKC) in dorsal root ga...

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Bibliographic Details
Main Authors: Yoshiyuki Sugimoto, Yozo Kojima, Atsushi Inayoshi, Kazuaki Inoue, Hiroko Miura-Kusaka, Kiyotoshi Mori, Osamu Saku, Hiroshi Ishida, Eri Atsumi, Yoshisuke Nakasato, Shiro Shirakura, Shin-ichiro Toki, Katsumi Shinoda, Nobuyuki Suzuki
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131930249X

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http://www.sciencedirect.com/science/article/pii/S134786131930249X

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