Engineered Fibroblast Extracellular Vesicles Attenuate Pulmonary Inflammation and Fibrosis in Bleomycin-Induced Lung Injury

Engineered Fibroblast Extracellular Vesicles Attenuate Pulmonary Inflammation and Fibrosis in Bleomycin-Induced Lung Injury

Pulmonary fibrosis is a progressive disease for which no curative treatment exists. We have previously engineered dermal fibroblasts to produce extracellular vesicles with tissue reparative properties dubbed activated specialized tissue effector extracellular vesicles (ASTEX). Here, we investigate t...

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Bibliographic Details
Main Authors: Abdulrahman Ibrahim, Alessandra Ciullo, Chang Li, Akbarshakh Akhmerov, Kiel Peck, K. C. Jones-Ungerleider, Ashley Morris, Alberto Marchevsky, Eduardo Marbàn, Ahmed Gamal Ibrahim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
extracellular vesicles (EVs)
genetic engineering
regenerative therapy
lung injury
inflammation
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.733158/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.733158/full

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