Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Sustained spermatogenesis in adult males and fertility recovery following germ cell depletion are dependent on undifferentiated spermatogonia. We previously demonstrated a key role for the transcription factor SALL4 in spermatogonial differentiation. However, whether SALL4 has broader roles within s...

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Bibliographic Details
Main Authors: Ai-Leen Chan, Hue M. La, Julien M.D. Legrand, Juho-Antti Mäkelä, Michael Eichenlaub, Mia De Seram, Mirana Ramialison, Robin M. Hobbs
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
germline stem cells
self-renewal
transcription factors
tumor suppressor genes
spermatogonia
SALL4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303582

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http://www.sciencedirect.com/science/article/pii/S2213671117303582

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