Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor

Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor

Abstract Phosphoinositide 3‐kinases, delta (PI3Kδ) and gamma (PI3Kγ) are enriched in immune cells and regulate the development and function of innate and adaptive immunity. Dual PI3Kδγ inhibitors are considered high value targets for their potential to treat a variety of immune‐mediated diseases, bu...

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Bibliographic Details
Main Authors: Yu Cai, Jun Yu, Ping Ren, Jianlin He, Zhipeng Wu, Kun Xiao, Hong Jia, Jian Wang, Yang Sai, Guangxiu Dai, Xiong Li, Weiguo Su, Karen Ngo, Glenda Castro, Paul D. Acton, Wai‐Ping Fung‐Leung, James P. Edwards, Jennifer Venable, Tadimeti S. Rao
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Pharmacology Research & Perspectives
Subjects:
collagen‐induced arthritis
HM5023507
PI3Kδ/γ dual inhibitor
Online Access:https://doi.org/10.1002/prp2.559

Internet

https://doi.org/10.1002/prp2.559

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