Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism

Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism

We investigated the influence of cannabidiol (CBD) on blood pressure (BP) and heart rate (HR) in spontaneously (SHR) and deoxycorticosterone (DOCA-salt) hypertensive rats. Hypertension was connected with increases in cardiac and plasma markers of lipid peroxidation in both models, whereas cardiac en...

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Bibliographic Details
Main Authors: Patryk Remiszewski, Iwona Jarocka-Karpowicz, Michał Biernacki, Anna Jastrząb, Eberhard Schlicker, Marek Toczek, Ewa Harasim-Symbor, Anna Pędzińska-Betiuk, Barbara Malinowska
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
2-arachidonoylglycerol
anandamide
cannabidiol
cannabinoid receptor
shr
doca-salt
endocannabinoids
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/21/4/1295

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https://www.mdpi.com/1422-0067/21/4/1295

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