Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Abstract Spinocerebellar ataxia type 14 (SCA14) is a subtype of the autosomal dominant cerebellar ataxias that is characterized by slowly progressive cerebellar dysfunction and neurodegeneration. SCA14 is caused by mutations in the PRKCG gene, encoding protein kinase C gamma (PKCγ). Despite the iden...

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Bibliographic Details
Main Authors: Maggie M. K. Wong, Stephanie D. Hoekstra, Jane Vowles, Lauren M. Watson, Geraint Fuller, Andrea H. Németh, Sally A. Cowley, Olaf Ansorge, Kevin Talbot, Esther B. E. Becker
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Acta Neuropathologica Communications
Subjects:
Ataxia
Stem cells
Purkinje cells
Neurodegeneration
Cerebellum
Protein kinase C gamma
Online Access:http://link.springer.com/article/10.1186/s40478-018-0600-7

Internet

http://link.springer.com/article/10.1186/s40478-018-0600-7

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