Estimating Detection Limits in Chromatography from Calibration Data: Ordinary Least Squares Regression vs. Weighted Least Squares

It is necessary to determine the limit of detection when validating any analytical method. For methods with a linear response, a simple and low labor-consuming procedure is to use the linear regression parameters obtained in the calibration to estimate the blank standard deviation from the residual...

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Bibliographic Details
Main Author: Juan M. Sanchez
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Separations
Subjects:
Online Access:http://www.mdpi.com/2297-8739/5/4/49