Enantiomeric Separation of Colchicine and Lacosamide by Nano-LC. Quantitative Analysis in Pharmaceutical Formulations

Enantiomeric Separation of Colchicine and Lacosamide by Nano-LC. Quantitative Analysis in Pharmaceutical Formulations

A chiral analytical methodology was developed by nano-liquid chromatography (nano-LC) enabling the enantiomeric separation of two chiral drugs, lacosamide (novel antiepileptic drug) and colchicine (antiuremic drug), commercialized as pure enantiomers. A capillary column lab-packed with an amylose tr...

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Bibliographic Details
Main Authors: Natalia Casado, Zhengjin Jiang, María Ángeles García, María Luisa Marina
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Separations
Subjects:
amylose-based stationary phase
chiral separation
enantiomers
colchicine
lacosamide
nano-LC
Online Access:https://www.mdpi.com/2297-8739/7/4/55

Internet

https://www.mdpi.com/2297-8739/7/4/55

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