HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation

HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation

Abstract Background Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to be elucidated. Methods We generated lentiviral constructs to overexpre...

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Bibliographic Details
Main Authors: Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu, Shaotang Li
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Epithelial–mesenchymal transition
HOXB8
Signal transducer and activator of transcription 3
Online Access:http://link.springer.com/article/10.1186/s12935-018-0717-6

Internet

http://link.springer.com/article/10.1186/s12935-018-0717-6

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